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ACTHAR OFFERS FLEXIBLE DOSING

Acthar is a highly purified sterile preparation of the adrenocorticotropic hormone in 16% gelatin to provide a prolonged release after subcutaneous (SC) or intramuscular (IM) injection.

Acthar offers flexible dosing for patients

For the treatment of acute exacerbations in adults with MS, the recommended dose is daily subcutaneous or intramuscular injections of 80-120 units for 2 to 3 weeks, as shown in the Acthar Prescribing Information.1

Access step-by-step injection videos below.

Dosing considerations

  • Dosage and frequency should be individualized according to the medical condition, severity of the disease, and initial response of the patient1
  • Acthar is available as a self-injection that patients can administer at home or wherever is best for them
  • Acthar is supplied in a 5-mL multidose vial containing 80 USP units per mL
  • Acthar should not be given intravenously1
  • Prolonged use may lead to adrenal insufficiency or recurrent symptoms which make it difficult to stop treatment. It may be necessary to taper the dose and gradually discontinue
  • In the prospective, open-label, randomized study, a 5-day course of Acthar was shown to effectively relieve symptoms of acute exacerbations of multiple sclerosis2
  • Side effects are similar to those seen with corticosteroids. Common side effects include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite, and weight gain1
  • Acthar should not be given intravenously. Prolonged use may lead to adrenal insufficiency or recurrent symptoms which make it difficult to stop treatment. It may be necessary to taper the dose and gradually discontinue

Please see Important Safety Information below. For a full list of indications, contraindications, warnings, precautions, and adverse events related to Acthar, please refer to the full Prescribing Information.

SC Injection Training Video

Step-by-step instructions on how to inject Acthar subcutaneously.

IM Injection Training Video

Step-by-step instructions on how to inject Acthar intramuscularly.

Dosing and administration support from Mallinckrodt

As part of our commitment to patients with MS relapses, Mallinckrodt provides a variety of home injection training and treatment support services:

  • Self-administration educational materials, including downloadable instructions and online videos for you to use with your staff and for patient training (visit the Resource Library)
  • The Acthar patient site offers self-injection instructions to help patients learn on their own time
  • The Acthar Information Kit is a collection of tools to help your patients better understand MS relapse symptoms and treatment with Acthar. These materials are available through an Acthar Specialty Sales Consultant

Acthar is indicated for the treatment of acute exacerbations of multiple sclerosis in adults. Controlled clinical trials have shown Acthar to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease.

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Important Safety Information

Contraindications